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February 18, 2019
Meta-analysis Finds Long-Term Benefits of Glucosamine Use in Knee Osteoarthritis
A recent meta-analysis found that Glucosamine sulfate is associated with improvements in pain, physical functioning, and joint structure in knee osteoarthritis. Glucosamines were evaluated in 6 of the 42 trials identified. Benefits of Celecoxib (NSAID) for pain were lost after a sub-group analysis for high quality trials. [Learn More]
February 11, 2019
Review of Pharmacological Treatment for Opioid Induced Constipation (OIC)
A recent review evaluates the use of PAMORAs for the treatment of OIC in non-cancer patients. Concerns exist that laxatives are ineffective in some patients because they fail to address the underlying mechanisms causing OIC. Numerous PAMORAs can be prescribed to treat constipation. The clinical considerations, including side effects, in using PAMORAs are discussed. [Learn More]